Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is emerging as a cause of secondary hypertension. Between 20 and 50% of patients with PHPT have hypertension, this being directly proportional to the calcemia. The elevation of blood pressure in PHPT is mediated by hypercalcemia that acts directly stimulating the contraction of muscle fibers of the arterial vessel wall, and increases plasma renin levels and the release of catecholamines.Objectives: (1) Det...

Introduction: Atrial natriuretic peptide (ANP), a member of the natriuretic peptide family, regulates several physiologic parameters including diuresis and natriuresis, and lowers arterial, blood pressure.It has been reported that plasma concentrations of ANP rise in response to acute hyperglycaemia in diabetes (1) (2) and this may indicate a neurohormonal response to limit target organ damage (3).We investigate if in situation chr...

Introduction: Its has been suggested that atrial natriuretic peptide (ANP) may contribuye to the development of microalbuminuria in diabetes mellitus.Plasma ANP concentration have been reported to be elevated in association with microalbuminuria, all of wich predict the future development of overt nephropathy in diabetes (1).Key players in neurohormonal activation include neuropeptides and their receptors wich include the ANP (2).<...

Introduction: Mechanism underlying glucose-mediated development and progression of diabetic complication are incompletely understood. Atrial natriuretic peptide (ANP) is a hormone released by atrial myocytes in response to acute and chronic extracellular volume expansion. Moderate hyperglycaemia (>400 mg/dl) in diabetic rats is associated with an elevation in circulating ANP levels and in GFR (glomerular filtration rate), (1) and play a role in the development of microalbu...

Introduction: The transsexuals are persons that having born with a biological sex feel to belong to the opposite sex. To obtain the sexual characters opposite to his (her) biological sex they need treatment with cross-sex hormones.This treatment with sexual steroids can produce changes in cardiovascular risk factors (CRF). There has been described that hyperhomocysteinemia is an independent CRF that is modifiable by cross-sex hormonal treatment (CHT) in ...